Follow the Biology
Follow the Biology couples Edge technology with the knowledge of specific proteins which are part of a biochemical pathway or biological network. To the extent that such proteins are reflective of activity within those pathways or networks, following their movements and location can be used to identify additional proteins which may also be markers of those pathways or networks.
Follow the Biology allows marker fingerprints or multicomponent cocktails to be identified within their biologically relevant environment. Researchers are able to follow the whole disease process from diagnosis to treatment since, in Edge technology:
- Fractionation is based on the density of biological compartments in which biology occurs
- Sample integrity is maintained, critical when determining early differences between normal and diseased samples.
- Groups of markers are identified within biologically relevant environments allowing the user to follow the biology throughout the disease process.
- Products complement, not compete with, down stream analyses - western blots, electrophoresis, mass spectrometry, and arrays
Edge Technology maintains biological context and tracks biological changes
(click here for a schematic demonstration)
Applications:
- Biomarker discovery
- Biomarker evaluation and validation
- Biological information on subcellular location
- Subcellular biology, cell biology and subcellular proteomics
- Low abundance protein isolation and enrichment
- Drug target discovery and characterization
- Binding studies and protein-protein interactions
- Clinical proteomics
- Nutriproteomics